The Mystery Inc. team is back and just as courageous, adventurous, humorous, and obsessed with cases as ever. Scooby and our gang of mystery-solving teens have been invited by famous comedian Jeff Foxworthy to help him move into an old mansion that he's just purchased, but when they find out that the mansion is haunted by the ghost of an old witch, this Southern-fried mystery takes a dramatic turn. Can our gang help Jeff save this mansion from destruction?