Career: Clooney lived with his aunt Rosemary while attending auditions, working as her chauffeur. His TV debut was 1984's Riptide, following it up with, ironically, a short-lived sitcom called ER. A string of disastrous projects followed before medical drama ER turned him into a major star in 1994. After five years Clooney left to concentrate on films. Projects include O Brother Where Art Thou?, Three Kings, The Perfect Storm, Intolerable Cruelty, Out of Sight, Ocean's Eleven, Up in the Air, The American and Gravity. Clooney's directorial debut was Confessions of a Dangerous Mind, and he has backed numerous projects as a producer. Away from showbusiness, he is involved with humanitarian causes.

Career: Made his movie debut in 1970's Hercules in New York, and gained a Golden Globe for Best Newcomer in 1976's Stay Hungry, but didn't become a star until Conan the Barbarian in 1982.The 1980s proved a successful decade thanks to hits Raw Deal, Predator, The Running Man, The Terminator and Twins, a rare foray into comedy. Terminator 2, True Lies and Junior followed these in the 1990s. In the latter years of his career he suffered a number of flops, and Terminator 3 was his last moderate hit. Today he is best known as the former Governor of California, although he has resurrected his big-screen career with roles in The Expendables 2, The Last Stand and The Tomb.

Career: Thurman made her mark in Dangerous Liaisons, and has been a star ever since. She made the controversial Henry and June in 1990, followed by more mainstream offerings Final Analysis and Mad Dog and Glory. Pulp Fiction proved she was more than just a pretty face in 1994. Over the course of her career, she has taken roles in the disastrous Batman and Robin and The Avengers, but fared better with the likes of Gattaca, Sweet and Lowdown, Paycheck, the Kill Bill movies, Be Cool and The Accidental Husband. In 2007, she was made a knight of the Ordre des Arts et des Lettres. Away from acting, Thurman is an active supporter of several charitable organisations. She is working on a third Kil Bill film and is one of Hollywood's biggest stars.

Career: Since his breakthrough, O'Donnell has appeared in a number of major motion pictures including Fried Green Tomatoes, the sensational Scent of a Woman, The Chamber, Circle of Friends and Vertical Limit. Big hits included fun offerings like The Three Musketeers. He also tried his hand at romantic comedy in films such as The Bachelor, and starred as Robin in the Batman franchise. For a time, he was tipped to be a true A-list star after building up an impressive body of work in a short time, but then he took some time away from the movies to be with his family and take some stage roles. He has since become a major small-screen presence in the hit series NCIS: Los Angeles.

Career: Silverstone began appearing in TV commercials, which led to a role in sitcom The Wonder Years in 1992. A year later, she made her first film, Crush. She then appeared in several Aerosmith music videos before landing the lead in Clueless in 1995. The film made her a major star, although she's since struggled to match its success. Other films she has appeared in include Batman & Robin (1997), Blast from the Past (1999), Love's Labours Lost (2000), Scooby Doo 2: Monsters Unleashed (2004), Alex Rider: Operation Stormbreaker (2006) and a cameo appearance in Tropic Thunder (2008). She has since appeared in various theatre productions, including a Broadway production of Time Stands Still, and such films as The Art of Getting By (2011), Who Gets The Dog? (2016) and Diary of a Wimpy Kid: The Long Haul (2017).

Career: Macpherson made her name as a supermodel, but later turned to acting. Her first major film was Sirens in 1994. Her dedication to the job meant she put on 20lbs to play a 1950s artist's model. While losing the weight, she and fitness expert Karen Voight devised a workout which led to a best-selling aerobics video. She continued her acting career with roles in Jane Eyre, The Edge, Batman and Robin, The Mirror Has Two Faces, and a short-lived role in Friends as Joey's flatmate. She became the host of Britain's Next Top Model in 2010. She has also enjoyed a number of successful business ventures, including a best-selling lingerie line, and is a European Ambassador for RED, an initiative set up by Bono and Bobby Shriver to raise money and awareness for the Global Fund to Fight Aids, Tuberculosis and Malaria.