Career: Determined to become a serious actor, Grammer spent two years at New York's Juilliard School. He then worked in theatre before making his TV debut in 1983 miniseries Kennedy. He had a stint in soap Another World, and in 1984 began playing Dr Frasier Crane in Cheers. After Cheers ended in 1993, he launched the hugely popular spin-off series Frasier. In addition to starring in 264 editions of the sitcom, he directed more than 30 episodes. Grammer has also starred in X-Men: The Last Stand, short-lived sitcoms Back to You and Hank, and the dramas Boss and Partners. He is also the voice of Sideshow Bob in The Simpsons.

Career: Madsen went on to star in a string of movies, including Candyman (1992), but her breakthrough role came in 2004 in Sideways, for which she was nominated for an Academy Award. Since then, she has starred in Firewall (2006), A Prairie Home Companion (2006), The Astronaut Farmer (2006), The Number 23 (2007) and Red Riding Hood (2011). She has also had recurring roles on the small screen in the likes of Scoundrels, The Event, and Witches of East End.

Career: David worked steadily on the stage throughout the 1980s and made his film debut in Bright Lights, Big City in 1988. He was later offered a role in Little Man Tate by former Yale classmate Jodie Foster, who remembered him from a student play. In 1992, he was in short-lived sitcom The Powers That Be and caught the eye of Frasier's creators, who noticed his resemblance to Kelsey Grammer and wrote the role of Niles especially for him. His performance in the long-running sitcom earned him four Emmy awards and a reported salary of $1million per episode for the last few seasons. Frasier came to an end in 2003 and David has since been seen in the film Down With Love and in various stage productions on Broadway and the West End. He won a Tony Award in 2007 for his performance in Kander and Ebb musical Curtains.

Career: After moving to Los Angeles, Leeves appeared in a series called Throb and made guest appearances in a number of shows, including Seinfeld and the miniseries Pandora's Clock. Her big break came in 1993 when she was cast as Daphne Moon in Cheers spin-off Frasier. Leeves has starred on Broadway as Sally Bowles in Cabaret and played parts in a variety of films, including Monty Python's The Meaning of Life (1983), To Live and Die in LA (1985), Miracle on 34th Street (1994) and Music of the Heart (1999). Since 2010, she has starred in the sitcom Hot in Cleveland.