In Nick's latest adventure, he follows the mighty Mississippi River from Minneapolis in the north all the way south to New Orleans. His journey starts with a helicopter ride along the northernmost stretch of the river, then he heads south along the Great River Road, swapping his pick-up for a Harley-Davidson along the way. Stopping at Mark Twain's birth town of Hannibal, Nick gets a sobering insight into the real lives of enslaved people along the Mississippi