Career: Four years later, he landed what would become his big break - the role of David in hit comedy series Roseanne. He played the articulate but unworldly lad for five years. This led to a series of similar parts, this time on the big screen, in movies such as I Know What You Did Last Summer and The Opposite of Sex. His CV also includes appearances in Vanilla Sky, My Name is Earl, Hancock and Table for Three. In 2006, he took to the stage in a Broadway production of The Little Dog Laughed (which also featured his first nude scene). He returned to the small screen for the sitcom The Big Bang Theory.

Career: Early in his career, Parsons worked on Off-Broadway productions and appeared on TV several times. He had a recurring role on Judging Amy, appeared on the TV series Ed and had minor roles in such films as Garden State (2004) and School for Scoundrels (2006). His big break came when he landed the role of Sheldon Cooper in The Big Bang Theory, a role that earned him four Primetime Emmy Awards for Outstanding Lead Actor in a Comedy Series and a Golden Globe for Best Performance by an Actor in a Television Series - Comedy or Musical. He went on to appear in the films The Big Year (2011), The Muppets (2011), Home (2015) and Hidden Figures (2016).

Career: MacNicol was cast in the off-Broadway play Crimes of the Heart in 1980. The production eventually moved to Broadway, and MacNicol won the Theatre World Award. It was also during this production that a casting agent noticed him and called him in to read for his eventual role in Sophie's Choice. In 1981, he appeared in his first film, Dragonslayer, opposite Sir Ralph Richardson. MacNicol is probably best known to TV viewers for his Emmy-winning role in Ally McBeal as eccentric attorney John Cage. After Ally McBeal ended, he went on to star in the drama NUMB3RS as physicist Dr Larry Fleinhardt, and he had a role as Tom Lennox in the sixth season of 24. MacNicol reprised his role as Lennox in the film 24: Redemption. He joined the cast of Grey's Anatomy in 2010.