Early-life: Seth Woodbury MacFarlane was born in Kent, Connecticut, on October 26, 1973 to Ann and Ronald. His sister is voice actor Rachael Ann MacFarlane. Seth knew from an early age that he wanted to develop his interest in animation. He began publishing a weekly comic strip entitled Walter Crouton for a local newspaper. His parents gave him an 8mm camera and he went on to study film, video and animation at the Rhode Island School of Design (RISD). During his time as a student, he performed stand-up and also created animated short The Life of Larry. On the back of this short, he was hired by Hanna-Barbara, where he worked as an animator and a writer for Cartoon Network's Cartoon Cartoons series. During his time at the studio, he also worked on Dexter's Laboratory, Cow and Chicken, I Am Weasel and Johnny Bravo. He also worked freelance on projects for Walt Disney, writing for Ace Ventura: Pet Detective.

Early-life: Seth Benjamin Gesshel-Green was born in Overbrook Park, Philadelphia, on February 8, 1974 to teachers Barbara and Herbert. He has a sister, Kaela. Seth has worked as an actor since the age of seven and his early credits include roles in The Hotel New Hampshire (1984), Billions for Boris (1984), Radio Days (1987) and Can't Buy Me Love (1987).