Career: Castellaneta started working at The Second City, an improvisational comedy theatre, in 1983 and stayed until 1987. During this time, he did voiceover work for various radio stations. He was hired to work on The Tracey Ullman Show and he started voicing Homer Simpson in The Simpsons, which was initially aired as a series of animated shorts. The Simpsons has since become a half-hour show and Castellaneta has continued to provide the voice of Homer. He has also voiced many other characters, including Grampa Simpson, Barney Gumble and Krusty the Clown. Castellaneta and his wife, Deb Lacusta, have also written several episodes of The Simpsons. He has done voice acting for a number of other animated series too, including Back to the Future, Aladdin, Earthworm Jim, Hey Arnold!, The Batman and Futurama. Besides voice acting, Castellaneta has had on screen parts in such series as Entourage, Everybody Loves Raymond, Friends, Greek, Parks and Recreation, How I Met Your Mother and Desperate Housewives. He has appeared in such films as K-9 (1989), The War of the Roses (1989), The Pursuit of Happyness (2006), Super 8 (2011) and Fantastic Four (2015).

Career: Cartwright's first professional voice acting role was in the animated series Richie Rich. She went on to appear on-screen in the leading role in TV film Marian Rose White (1982) and her first feature film was Twilight Zone: The Movie (1983). In 1987, she auditioned for a role on The Simpsons while it was a series of animated shorts on The Tracey Ullman Show. She voiced Bart Simpson for three seasons on The Tracey Ullman Show and has retained the role ever since The Simpsons became a half-hour show. Cartwright also voices other characters on The Simpsons, including Nelson Muntz, Ralph Wiggum and Todd Flanders. Besides The Simpsons, Cartwright has voiced Chuckie Finster in Rugrats and All Grown Up!, Mindy in Animaniacs, Rufus in Kim Possible and many other characters. She has also appeared on-camera in The Fresh Prince of Bel-Air, 24, Empty Nest and Godzilla (1998).

Career: Kavner won her first notable role on popular comedy series Rhoda as Brenda Morgenstern in 1974 and stayed on until it finished four years later, winning an Emmy award for her performance. She then moved on to guest stints on The Tracey Ullman Show, in which a number of animated shorts were to be included. Producers were looking for voices for the cartoons and enlisted the actress. This just happened to turn into The Simpsons, which proved a runaway success. Despite voicing Marge since 1988 (and reportedly earning more than $400,000 per episode), Kavner has fitted in several film roles over the years, including her first starring role in This Is My Life from 1992.

Career: Smith appeared in a number of Broadway productions before landing her first film roles in Heaven Help Us (1985) and The Legend of Billie Jean (1985). She moved to Los Angeles in 1986 and landed a recurring role in the TV series Brothers. In 1987, she auditioned for The Simpsons shorts on The Tracey Ullman Show. She has voiced Lisa Simpson ever since and the series was spun into a half-hour show in 1989. Away from The Simpsons, Smith played Louise in the sitcom Herman's Head. She has also appeared in such series as Dharma & Greg, Dead Like Me, Mad Men, The Big Bang Theory and The Mindy Project. Her film credits include City Slickers (1991), Jingle All the Way (1996) and As Good as It Gets (1997).

Career: In 1996, MacFarlane created a sequel to The Life of Larry entitled Larry & Steve. He wanted to move into prime-time animation and pitched Family Guy to Fox while he was still working at Hanna-Barbara. They offered him $50,000 to produce a pilot at a time when most prime-time animated shows cost $1million per episode. He spent six months working on the pilot and delivered a product that Fox loved. Family Guy premiered in January 1999. MacFarlane not only writes episodes of Family Guy, he also voices the main male characters. The show has been a big success and it led to MacFarlane co-creating American Dad and The Cleveland Show. In recent years, MacFarlane has moved into live-action comedy. He had a big success with the film Ted in 2012. He also played the lead role in A Million Ways to Die in the West (2014).