Career: Rogen was cast in a major supporting role and credited as a co-producer in Apatow's directorial debut, The 40-Year-Old Virgin. After Rogen received critical praise for that performance, Universal Pictures agreed to cast him as the lead in Apatow's directorial feature films Knocked Up and Funny People. Rogen and his comedy partner Evan Goldberg co-wrote the films Superbad, Pineapple Express, and The Green Hornet. Rogen has done voice work for the films Horton Hears a Who!, Kung Fu Panda, Monsters vs. Aliens, and Paul.

Career: After appearing in various magazine and TV commercials, Heigl made her screen debut in 1992 film That Night. The acting bug bit, and only two years later she was cast in My Father the Hero, alongside French icon Gerard Depardieu. More roles followed, including Under Siege 2: Dark Territory, Disney drama Wish Upon a Star, and horror flick Valentine. She's since been busy with both films, TV and modelling work, with her most notable achievements coming thanks to being cast as Isabel Evans in sci-fi series Roswell in 1999, before winning the part of Dr Izzie Stevens in top-rated medical drama Grey's Anatomy. She's since enjoyed movie success with Knocked Up and 27 Dresses.

Career: Following a short course at Oxford University, Rudd helped to produce a performance at the Globe Theatre and played Hamlet, directed by Ben Kingsley. His first TV work came in 1992, including a year-long stint on soap opera Sisters. More stage work followed before his big break came when he was cast as the love interest in hit movie Clueless. He's been in demand ever since, appearing in such diverse projects as Romeo + Juliet, The Cider House Rules, The Object of My Affection, Jackie Chan's Gen-X Cops 2 and Anchorman: The Legend of Ron Burgundy. He became a semi-regular in Friends in 2002. Since then, he has appeared in a number of hit comedy films, including The 40-Year-Old Virgin, Night at the Museum, The Ex, Knocked Up, Forgetting Sarah Marshall, Role Models, Year One, Dinner for Schmucks and Ant-Man.

Career: In 2004, Mann played a nurse in short-lived medical drama Birdland and a year later she was chosen from an open audition of 500 candidates to star in The Cable Guy (1996). Since then she has starred in a number of big-screen comedies, including George of the Jungle (1997), Big Daddy (1999), The 40-Year-Old Virgin (2005), Knocked Up (2007), 17 Again (2009) and This Is 40 (2012). A number of her films have been directed by her husband, Judd Apatow. Her recent credits include The Bling Ring (2013), Mr Peabody & Sherman (2014) and The Other Woman (2014).

Career: Segel's first major acting role was in 1999 NBC comedy drama Freaks and Geeks. He had a recurring role on CSI: Crime Scene Investigation before his breakthrough in CBS sitcom How I Met Your Mother. Success followed on the big screen in Knocked Up (2007), Forgetting Sarah Marshall (2008), I Love You, Man (2009), Get Him to the Greek (2010), The Muppets (2011), Friends with Benefits (2011), Bad Teacher (2011), This Is 40 (2012), The Five-Year Engagement (2012) and Sex Tape (2014).

Career: Baruchel went on to star in Judd Apatow's short-lived sitcom Undeclared. In 2004, he played a boxing hopeful on the big screen in Clint Eastwood's Million Dollar Baby. His other film credits include Knocked Up (2007), Tropic Thunder (2008), Nick and Norah's Infinite Playlist (2008), Night at the Museum: Battle of the Smithsonian (2009), This Is the End (2013) and RoboCop (2014). He voices Hiccup in the How to Train Your Dragon film and TV franchise.

Career: Hill began writing his own plays and performing them in the Black and White bar in the East Village neighbourhood of New York. A friendship with Dustin Hoffman's children led to his first film role in I Heart Huckabees (2004). Parts in various films and TV series followed until he landed a lead role in hugely popular teen comedy Superbad (2007). Since then, he has appeared in Forgetting Sarah Marshall (2008), The Invention of Lying (2009), Cyrus (2010), Get Him to the Greek (2010), Moneyball (2011), The Sitter (2011), 21 Jump Street (2012) and the 2014 sequel 22 Jump Street, This Is the End (2013) and The Wolf of Wall Street (2014). He has also lent his voice to the TV series Allen Gregory and the films How to Train Your Dragon (2010) and its 2014 sequel, Megamind (2010) and The Lego Movie (2014).